An embedded gene selection method using knockoffs

geno-type

An embedded gene choice methodology utilizing knockoffs optimizing neural community

 

Background: Gene alternative refers to find a small subset of discriminant genes from the gene expression profiles. The way in which to decide on genes that affect specific phenotypic traits efficiently is an important evaluation work throughout the topic of biology. The neural group has greater changing into functionality when dealing with nonlinear info, and it’ll in all probability seize choices robotically and flexibly. On this work, we advise an embedded gene alternative methodology using neural group.

 

The important genes could also be obtained by calculating the burden coefficient after the teaching is completed. In an effort to treatment the difficulty of black area of neural group and extra make the teaching outcomes interpretable in neural group, we use the idea of knockoffs to assemble the knockoff attribute genes of the distinctive attribute genes. This system not solely make each attribute gene to compete with each other, however moreover make each attribute gene compete with its knockoff attribute gene. This methodology could assist to select the essential factor genes that affect the decision-making of neural networks.

 

Outcomes: We use maize carotenoids, tocopherol methyltransferase, raffinose family oligosaccharides and human breast most cancers dataset to do verification and analysis.

 

Conclusions: The experiment outcomes show that the knockoffs optimizing neural group methodology has greater detection impression than the other current algorithms, and particularly for processing the nonlinear gene expression and phenotype info.

 

geno-type

geno-type

Fenretinide

GP8861-10MG 10 mg
EUR 112.8

Fenretinide

GP8861-25MG 25 mg
EUR 170.4

Fenretinide

205430 100.0mg
EUR 150

Fenretinide

GP8861-10 10
EUR 63.3

Fenretinide

GP8861-25 25
EUR 110.7

Fenretinide

T1872-10mg 10mg Ask for price
Description: Fenretinide

Fenretinide

T1872-1g 1g Ask for price
Description: Fenretinide

Fenretinide

T1872-1mg 1mg Ask for price
Description: Fenretinide

Fenretinide

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Description: Fenretinide

Fenretinide

T1872-5mg 5mg Ask for price
Description: Fenretinide

Fenretinide [CAS# 65646-68-6]

F-4077 10 mg
EUR 39

Fen1/ Rat Fen1 ELISA Kit

ELI-27513r 96 Tests
EUR 1063.2

1000 ug/mL Fenthion in Acetone

S-2010-AC 1ML
EUR 168

1000 ug/mL Fenobucarb in Acetone

S-4610-AC 1ML
EUR 94.8

FEN1

enz-468 5µg
EUR 60
Description: Recombinant Human Flap Structure-Specific Endonuclease 1

FEN1

CSB-CL008585HU 10 μg plasmid + 200μl Glycerol Ask for price

1000 ug/mL Fenpyroximate in Acetone

S-5804 1ML
EUR 230.4

FEN1 siRNA

20-abx916746
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FEN1 siRNA

20-abx916747
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

FEN1-IN-2

T40931-10mg 10mg Ask for price
Description: FEN1-IN-2

FEN1-IN-2

T40931-1g 1g Ask for price
Description: FEN1-IN-2

FEN1-IN-2

T40931-1mg 1mg Ask for price
Description: FEN1-IN-2

FEN1-IN-2

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Description: FEN1-IN-2

FEN1-IN-2

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Description: FEN1-IN-2

FEN1-IN-1

T15274-10mg 10mg Ask for price
Description: FEN1-IN-1

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T15274-1g 1g Ask for price
Description: FEN1-IN-1

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Description: FEN1-IN-1

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Description: FEN1-IN-1

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Description: FEN1-IN-1

FEN1-IN-4

T8545-10mg 10mg Ask for price
Description: FEN1-IN-4

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Description: FEN1-IN-4

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Description: FEN1-IN-4

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Description: FEN1-IN-4

FEN1-IN-4

T8545-5mg 5mg Ask for price
Description: FEN1-IN-4

FEN1-IN-3

T9147-10mg 10mg Ask for price
Description: FEN1-IN-3

FEN1-IN-3

T9147-1g 1g Ask for price
Description: FEN1-IN-3

FEN1-IN-3

T9147-1mg 1mg Ask for price
Description: FEN1-IN-3

FEN1-IN-3

T9147-50mg 50mg Ask for price
Description: FEN1-IN-3

FEN1-IN-3

T9147-5mg 5mg Ask for price
Description: FEN1-IN-3

1000 ug/mL Fenamidone in HPLC Acetonitrile

LCS-4966 1ML
EUR 346.8

1000 ug/mL Fenazaquin in HPLC Acetonitrile

LCS-6019 1ML
EUR 354

1000 ug/mL of Fenitrothion in Acetone 1mL Ampule

S-2001 1ML
EUR 60

Lenti ORF particles, Fen1 (GFP-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL

MR220960L4V 200 µl Ask for price

Lenti ORF particles, Fen1 (GFP-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL

RR207787L4V 200 µl Ask for price

1000 ug/mL (E)-Fenpyroximate in Acetonitrile

S-6179 1ML
EUR 121.2

Lenti ORF particles, FEN1 (Myc-DDK tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL

RC201785L1V 200 µl Ask for price

Lenti ORF particles, FEN1 (mGFP-tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL

RC201785L2V 200 µl Ask for price

Lenti ORF particles, FEN1 (Myc-DDK tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL

RC201785L3V 200 µl Ask for price

Lenti ORF particles, FEN1 (mGFP-tagged) - Human flap structure-specific endonuclease 1 (FEN1), 200ul, >10^7 TU/mL

RC201785L4V 200 µl Ask for price

Lenti ORF particles, Fen1 (Myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL

MR220960L3V 200 µl Ask for price

Fen1 (untagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), (10 ug)

RN207787 10 µg Ask for price

FEN1 protein

30R-1442 100 ug
EUR 476.4
Description: Purified recombinant Human FEN1 protein

FEN1 Rabbit pAb

A1175-100ul 100 ul
EUR 369.6

FEN1 Rabbit pAb

A1175-200ul 200 ul
EUR 550.8

FEN1 Rabbit pAb

A1175-20ul 20 ul
EUR 219.6

FEN1 Rabbit pAb

A1175-50ul 50 ul
EUR 267.6

FEN1 Rabbit pAb

A0129-100ul 100 ul
EUR 369.6

FEN1 Rabbit pAb

A0129-200ul 200 ul
EUR 550.8

FEN1 Rabbit pAb

A0129-20ul 20 ul Ask for price

FEN1 Rabbit pAb

A0129-50ul 50 ul Ask for price

FEN1 Rabbit mAb

A8999 20 μL
EUR 18

FEN1 Rabbit pAb

E2501175 100ul
EUR 225
Description: Available in various conjugation types.

FEN1 Rabbit pAb

E2381904 100ul
EUR 225
Description: Available in various conjugation types.

FEN1 Rabbit mAb

E2R26747 100ul
EUR 255
Description: Available in various conjugation types.

FEN1 Rabbit mAb

52758 100ul
EUR 499

FEN1 Rabbit mAb

59492 100ul
EUR 339

Lenti ORF particles, Fen1 (Myc-DDK-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), 200ul, >10^7 TU/mL

RR207787L3V 200 µl Ask for price

Fen1 (untagged) - Mouse flap structure specific endonuclease 1 (Fen1), (10ug)

MC208478 10 µg Ask for price

Fen1 (GFP-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), (10ug)

MG220960 10 µg Ask for price

FEN1 (GFP-tagged) - Human flap structure-specific endonuclease 1 (FEN1)

RG201785 10 µg Ask for price

FEN1 (untagged)-Human flap structure-specific endonuclease 1 (FEN1)

SC110892 10 µg Ask for price

1000 ug/mL (E)-Fenpyroximate in HPLC Acetonitrile

LCS-6179 1ML
EUR 354

1000 ug/mL Fenpyroximate in HPLC Acetonitrile

LCS-6387 1ML
EUR 194.4

1000 ug/mL Fenthion sulfoxide in Acetonitrile

S-4316-ACN 1ML
EUR 111.6

FEN1 antibody

10R-1738 100 ug
EUR 614.4
Description: Mouse monoclonal FEN1 antibody

FEN1 antibody

70R-17281 50 ul
EUR 522
Description: Rabbit polyclonal FEN1 antibody

FEN1 antibody

70R-1605 100 ug
EUR 452.4
Description: Rabbit polyclonal FEN1 antibody raised against the C terminal of FEN1

FEN1 antibody

70R-31706 100 ug
EUR 392.4
Description: Rabbit polyclonal FEN1 antibody

FEN1 antibody

70R-49736 100 ul
EUR 292.8
Description: Purified Polyclonal FEN1 antibody

FEN1 Antibody

33763-100ul 100ul
EUR 302.4

FEN1 Antibody

33763-50ul 50ul
EUR 224.4

FEN1 Antibody

32204-100ul 100ul
EUR 302.4

FEN1 Antibody

ABD13091 100 ug
EUR 525.6

FEN1 Antibody

ABD3172 100 ug
EUR 525.6

FEN1 Antibody

ABD6309 100 ug
EUR 525.6

FEN1 Antibody

DF3172 200ul
EUR 420

FEN1 Antibody

CSB-PA926648- each
EUR 402
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

FEN1 Antibody

CSB-PA926648-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

FEN1 Antibody

CSB-PA008585KA01HU- each
EUR 402
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

FEN1 Antibody

CSB-PA008585KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:2000, IHC:1:50-1:200

FEN1 Antibody

1-CSB-PA008585GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

FEN1 Antibody

1-CSB-PA002510
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against FEN1. Recognizes FEN1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

FEN1 Antibody

E11-10585C 100μg
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

E033763 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FEN1 Antibody

E19-3172 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

E19-6309 100μg/100μl
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

8C10585 50ug
EUR 368
Description: FEN1 Antibody

FEN1 Antibody

CAC11682-100ul 100ul
EUR 314

FEN1 Antibody

CAC11682-50ul 50ul
EUR 199.2

FEN-1 Antibody

RQ5695 100 ug
EUR 356.15
Description: Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene. It is mapped to 11q12.2. The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

FEN1 Antibody

E309179 200ul
EUR 275
Description: Available in various conjugation types.

FEN1 Antibody

E38PA1417 100ul
EUR 225
Description: Available in various conjugation types.

FEN1 Antibody

DF6309 100ul
EUR 280
Description: Human,Mouse,Rat

FEN1 Antibody

DF6309-100ul 100ul
EUR 280

FEN1 Antibody

DF6309-200ul 200ul
EUR 350

FEN1 Antibody

E91175 100ul
EUR 255
Description: Available in various conjugation types.

FEN1-IN-SC13

T9743-10mg 10mg Ask for price
Description: FEN1-IN-SC13

FEN1-IN-SC13

T9743-1g 1g Ask for price
Description: FEN1-IN-SC13

FEN1-IN-SC13

T9743-1mg 1mg Ask for price
Description: FEN1-IN-SC13

FEN1-IN-SC13

T9743-50mg 50mg Ask for price
Description: FEN1-IN-SC13

FEN1-IN-SC13

T9743-5mg 5mg Ask for price
Description: FEN1-IN-SC13

FEN1 Antibody

32204 100ul
EUR 439

FEN1 Antibody

33763 100ul
EUR 319

Fen1 (Myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1)

MR220960 10 µg Ask for price

Fen1 (Myc-DDK-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), (10 ug)

RR207787 10 µg Ask for price

1000 ug/mL Fenthion-sulfone in HPLC Acetonitrile

LCS-6063 1ML
EUR 294

FEN1 ELISA KIT|Human

EF009610 96 Tests
EUR 826.8

FEN1 (Myc-DDK-tagged)-Human flap structure-specific endonuclease 1 (FEN1)

RC201785 10 µg Ask for price

anti- FEN1 antibody

FNab03075 100µg
EUR 606.3
Description: Antibody raised against FEN1

Fen1 ORF Vector (Rat) (pORF)

ORF067064 1.0 ug DNA
EUR 607.2

1000 ug/mL Fensulfothion-oxon in HPLC Acetonitrile

LCS-6209 1ML
EUR 644.4

1000 ug/mL Fenhexamid in Acetonitrile Volume: 1mL Ampule

S-4962-ACN 1ML
EUR 116.4

1000 ug/mL Fenamidone in Acetonitrile Volume: 1mL Ampule

S-4966-ACN 1ML
EUR 121.2

Lenti ORF clone of Fen1 (mGFP-tagged) - Mouse flap structure specific endonuclease 1 (Fen1)

MR220960L4 10 µg Ask for price

Rat FEN1 shRNA Plasmid

20-abx986959
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FEN1 (Center) Rabbit pAb

E2614818 100ul
EUR 225
Description: Available in various conjugation types.

Lenti ORF clone of Fen1 (Myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1)

MR220960L3 10 µg Ask for price

Lenti ORF clone of Fen1 (mGFP-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), (10 ug)

RR207787L4 10 µg Ask for price

FEN1 cloning plasmid

CSB-CL008585HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the FEN1 gene.

FEN1 ORF Vector (Human) (pORF)

ORF004018 1.0 ug DNA
EUR 114

Fen1 ORF Vector (Mouse) (pORF)

ORF044773 1.0 ug DNA
EUR 607.2

Fen1 3'UTR GFP Stable Cell Line

TU254569 1.0 ml Ask for price

Fen1 3'UTR GFP Stable Cell Line

TU156502 1.0 ml Ask for price

FEN1 3'UTR GFP Stable Cell Line

TU057883 1.0 ml
EUR 1672.8

Fen1 (untagged) - Mouse flap structure specific endonuclease 1 (Fen1), transcript variant 2

MC227399 10 µg Ask for price

Fen1 (untagged) - Mouse flap structure specific endonuclease 1 (Fen1), transcript variant 3

MC227400 10 µg Ask for price

Lenti ORF clone of Fen1 (Myc-DDK-tagged ORF) - Rat flap structure-specific endonuclease 1 (Fen1), (10 ug)

RR207787L3 10 µg Ask for price

Rad2 / FEN1 (pS187) Antibody

abx215327-100ug 100 ug
EUR 526.8

Human FEN1 shRNA Plasmid

20-abx951559
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

FEN1 Blocking Peptide

20-abx062611
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

FEN1 Blocking Peptide

33R-7232 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FEN1 antibody, catalog no. 70R-1605

FEN1 Blocking Peptide

DF6309-BP 1mg
EUR 234

FEN1 Blocking Peptide

DF3172-BP 1mg
EUR 234

FEN1P1 ORF Vector (Human) (pORF)

ORF019564 1.0 ug DNA Ask for price

Fen1 (myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), transcript variant 2

MR229610 10 µg Ask for price

Fen1 (myc-DDK-tagged) - Mouse flap structure specific endonuclease 1 (Fen1), transcript variant 3

MR229611 10 µg Ask for price

1000 ug/mL Fenbutatin-oxide in LCMS Grade AcetoneVolume: 1mL Ampule

LCS-1999-AC 1ML
EUR 217.2

1000 ug/mL Fensulfothion-oxon-sulfone in HPLC Acetonitrile

LCS-6210 1ML
EUR 368.4

FEN-1 Polyclonal Antibody

40922-100ul 100ul
EUR 302.4

FEN-1 Polyclonal Antibody

40922-50ul 50ul
EUR 224.4

FEN1 Conjugated Antibody

C32204 100ul
EUR 476.4

FEN-1 Polyclonal Antibody

ABP51337-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of FEN-1 from Human, Mouse, Rat. This FEN-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FEN-1 at AA range: 60-140

FEN-1 Polyclonal Antibody

ABP51337-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of FEN-1 from Human, Mouse, Rat. This FEN-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FEN-1 at AA range: 60-140

FEN-1 Polyclonal Antibody

ABP51337-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of FEN-1 from Human, Mouse, Rat. This FEN-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human FEN-1 at AA range: 60-140

FEN-1 Polyclonal Antibody

ES2336-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against FEN-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

FEN-1 Polyclonal Antibody

ES2336-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against FEN-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

FEN1 ELISA Kit (Human) (OKEH08213)

OKEH08213 96 Wells
EUR 1075.2
Description: Description of target: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Competitive ELISA;Sensitivity: 0.136ng/mL

Fen1 ELISA Kit (Mouse) (OKEH08214)

OKEH08214 96 Wells
EUR 1075.2
Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.27ng/mL

FEN-1 Polyclonal Antibody

E040922 100μg/100μl
EUR 255
Description: Available in various conjugation types.

FEN-1 Polyclonal Antibody

E20-71689 100ug
EUR 225
Description: Available in various conjugation types.

Human FEN1 Protein Lysate 20ug

IHUFEN1PLLY20UG each
EUR 213
Description: Human FEN1 Protein Lysate 20ug

FEN1 Protein Vector (Rat) (pPM-C-HA)

PV268256 500 ng
EUR 723.6

FEN1 Recombinant Protein (Rat)

RP201188 100 ug Ask for price

FEN1 Protein Vector (Rat) (pPB-C-His)

PV268254 500 ng
EUR 723.6

FEN1 Protein Vector (Rat) (pPB-N-His)

PV268255 500 ng
EUR 723.6

FEN1 Protein Vector (Rat) (pPM-C-His)

PV268257 500 ng
EUR 723.6

OPPA02024-5UG - FEN1 Protein

OPPA02024-5UG 5ug
EUR 70

FEN1 Protein Vector (Human) (pPM-C-HA)

PV016071 500 ng
EUR 394.8

FEN1 Protein Vector (Mouse) (pPM-C-HA)

PV179092 500 ng
EUR 723.6

AAP46097-100UG - FEN1 Peptide

AAP46097-100UG 100ug
EUR 99

FEN1 (A119) polyclonal antibody

E43S1989 100ul
EUR 225
Description: Available in various conjugation types.

Rad2/FEN1 (Phospho- Ser187) Antibody

ABF8505 100 ug
EUR 525.6

FEN1 Protein Vector (Human) (pPB-C-His)

PV016069 500 ng
EUR 394.8

FEN1 Protein Vector (Human) (pPB-N-His)

PV016070 500 ng
EUR 394.8

FEN1 Protein Vector (Human) (pPM-C-His)

PV016072 500 ng
EUR 394.8

FEN1 Protein Vector (Mouse) (pPB-C-His)

PV179090 500 ng
EUR 723.6

FEN1 Protein Vector (Mouse) (pPB-N-His)

PV179091 500 ng
EUR 723.6

FEN1 Protein Vector (Mouse) (pPM-C-His)

PV179093 500 ng
EUR 723.6

FEN1 Recombinant Protein (Human)

RP012052 100 ug Ask for price

FEN1 Recombinant Protein (Mouse)

RP134315 100 ug Ask for price

FEN1 3'UTR Luciferase Stable Cell Line

TU007883 1.0 ml
EUR 1672.8

Fen1 3'UTR Luciferase Stable Cell Line

TU106502 1.0 ml Ask for price

Fen1 3'UTR Luciferase Stable Cell Line

TU204569 1.0 ml Ask for price

OKEH08213-96W - FEN1 ELISA Kit (Human)

OKEH08213-96W 96Wells
EUR 725

OKEH08214-96W - Fen1 ELISA Kit (Mouse)

OKEH08214-96W 96Wells
EUR 725

OACA09745-50UG - FEN1 Antibody

OACA09745-50UG 50ug
EUR 179

OAAN00260-50UL - FEN1 Antibody

OAAN00260-50UL 50ul
EUR 149

Mouse Monoclonal FEN-1 Antibody

TA346946 100 µl Ask for price

Mouse Monoclonal FEN-1 Antibody

TA346947 100 µl Ask for price

Fen1 sgRNA CRISPR Lentivector set (Rat)

K7115801 3 x 1.0 ug
EUR 406.8

OAAJ06783-100UL - FEN1 Antibody

OAAJ06783-100UL 100uL
EUR 319

OAGA01707-100UL - FEN1 Antibody

OAGA01707-100UL 100ul
EUR 369

OAGA08754-100UL - FEN1 Antibody

OAGA08754-100UL 100ul
EUR 369

OAGA08755-100UL - FEN1 Antibody

OAGA08755-100UL 100ul
EUR 369

OAAB18308-100UL - FEN1 Antibody

OAAB18308-100UL 100ul
EUR 389

 

Single cell transcriptomes reveal expression patterns of chemoreceptor genes in olfactory sensory neurons of the Caribbean spiny lobster, Panulirus argus

 

 

Background: Crustaceans categorical a lot of programs of receptor genes of their antennules, which house olfactory sensory neurons (OSNs) and non-olfactory chemosensory neurons. Transcriptomics analysis reveal that candidate chemoreceptor proteins embrace variant Ionotropic Receptors (IRs) along with every co-receptor IRs and tuning IRs, Transient Receptor Potential (TRP) channels, Gustatory Receptors, epithelial sodium channels, and class A G-protein coupled receptors (GPCRs). The Caribbean spiny lobster, Panulirus argus, expresses in its antennules nearly 600 IRs, 17 TRP channels, 1 Gustatory Receptor, 7 epithelial sodium channels, 81 GPCRs, 6 G proteins, and dozens of enzymes in signaling pathways.

 

Nonetheless, the exact combinatorial expression patterns of these proteins in single sensory neurons normally aren’t acknowledged for any crustacean, limiting our understanding of how their chemosensory strategies encode chemical prime quality.

 

Outcomes: The aim of this analysis was to utilize transcriptomics to elucidate expression patterns of chemoreceptor genes in OSNs of P. argus. We generated and analyzed transcriptomes from 7 single OSNs, just a few of which have been confirmed to reply a meals odor, along with an additional 7 multicell transcriptomes from preparations containing few (2-4), a lot of (ca. 15), or many (ca. 400) OSNs. We found that each OSN expressed the similar 2 co-receptor IRs (IR25a, IR93a) nevertheless

 

not the other 2 antennular coIRs (IR8a, IR76b), 9-53 tuning IRs nevertheless only one to some in extreme abundance, the similar 5 TRP channels plus as a lot as 5 further TRPs, 12-17 GPCRs along with the similar 5 expressed in every single cell transcriptome, the similar Three G proteins plus others, many enzymes throughout the signaling pathways, nevertheless no Gustatory Receptors or epithelial sodium channels. One of the best distinction in receptor expression among the many many OSNs was the identification of the tuning IRs.

 

Conclusions: Our outcomes current an preliminary view of the combinatorial expression patterns of receptor molecules in single OSNs in a single species of decapod crustacean, along with receptors straight involved in olfactory transduction and others probably involved in modulation. Our outcomes moreover counsel variations in receptor expression in OSNs vs. completely different chemosensory neurons.

Camel Genetic Belongings Conservation by Tourism: A Key Sociocultural Technique of Camelback Leisure Driving

 

  • Camels are distinctive components, which can be comprised inside journey journey companies promoting ecotourism actions. Such recreations contribute to sustainable livelihoods for native communities and educational empowerment within the path of nature and its conservation. At present, some native camel breeds’ survival reduces to this animal-based leisure enterprise and its reliability to hold out and promote custom-made firms By conducting an on-site questionnaire to prospects participating in camelback driving excursions, we assessed the motivational elements affecting participation, satisfaction, and loyalty on this tourism part that can have made it socially differentiated.

 

  • The sixfold combination of staff effectivity, custom geography, quite a few and humane shut interaction, camel conduct and effectivity, sociotemporal context, and constructive earlier experience consists of the elemental dimensions that designate purchaser satisfaction and return intention likelihood inside this leisure enterprise.

 

  • Purchaser knowledge is essential for stakeholders to assemble personalised driving experiences and align revenue with environmental sustainability and biodiversity mainstream issues into their frequently operations. In flip, house camel vacationer rides is likely to be managed as a viable path to nature conservation by serving to endangered native breeds to stay away from their helpful devaluation and potential extinction.

Connexin Genes Variants Related to Non-Syndromic Listening to Impairment: A Systematic Evaluate of the International Burden

Mutations in connexins are the commonest causes of listening to impairment (HI) in lots of populations. Our goal was to overview the worldwide burden of pathogenic and certain pathogenic (PLP) variants in connexin genes related to HI. We carried out a scientific overview of the literature primarily based on focused inclusion/exclusion standards of publications from 1997 to 2020. The databases used had been PubMed, Scopus, Africa-Extensive Data, and Net of Science.
The protocol was registered on PROSPERO, the Worldwide Potential Register of Systematic Critiques, with the registration quantity “CRD42020169697”. The info extracted had been analyzed utilizing Microsoft Excel and SPSS model 25 (IBM, Armonk, New York, United States). A complete of 571 impartial research had been retrieved and thought of for knowledge extraction with nearly all of research (47.8% (n = 289)) carried out in Asia.
Focused sequencing was discovered to be the commonest method utilized in investigating connexin gene mutations. We recognized seven connexin genes that had been related to HI, and GJB2 (520/571 publications) was probably the most studied among the many seven.
Excluding PLP in GJB2GJB6, and GJA1 the opposite connexin gene variants (thus GJB3GJB4GJC3, and GJC1 variants) had conflicting affiliation with HI. Biallelic GJB2 PLP variants had been the commonest and widespread variants related to non-syndromic listening to impairment (NSHI) in numerous world populations however absent in most African populations.
The commonest GJB2 alleles discovered to be predominant in particular populations embrace; p.Gly12ValfsTer2 in Europeans, North Africans, Brazilians, and Individuals; p.V37I and p.L79Cfs in Asians; p.W24X in Indians; p.L56Rfs in Individuals; and the founder mutation p.R143W in Africans from Ghana, or with putative Ghanaian ancestry.
The current overview means that solely GJB2 and GJB3 are acknowledged and validated HI genes. The findings name for an in depth investigation of the opposite connexin genes in lots of populations to elucidate their contributions to HI, in an effort to enhance gene-disease pair curations, globally.

 

 

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EUR 122.4

Afatinib

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EUR 374.4

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Afatinib

GW6150-1 1
EUR 171.5

Afatinib

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Afatinib

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Afatinib (BIBW2992)

A8247-10 10 mg
EUR 265.2
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5 5 mg
EUR 176.4
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-5.1 10 mM (in 1mL DMSO)
EUR 292.8
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-50 50 mg
EUR 614.4
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib (BIBW2992)

A8247-S Evaluation Sample
EUR 97.2
Description: Afatinib (BIBW2992), an irreversible inhibitor of the ErbB family of tyrosine kinases, downregulates ErbB signalling by binding to the kinase domains of epidermal growth factor receptor (EGFR)/ human epidermal growth factor receptor 2 (HER2) with IC50 of 0.5 nM and 14nM, respectively.

Afatinib dimaleate

A3145-10 10 mg
EUR 265.2
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5 5 mg
EUR 176.4
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-5.1 10 mM (in 1mL DMSO)
EUR 142.8
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib dimaleate

A3145-50 50 mg
EUR 614.4
Description: Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Afatinib (dimaleate)

HY-10261A 200mg
EUR 374.4

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120204 100.0mg
EUR 90

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EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992

SM-101000-5 5 mg
EUR 196.8

EGFR/HER2 kinase inhibitor (>99%, M.wt 485.94) (Afatinib/BIBW-2992

SM-101000-50 50 mg
EUR 781.2

Afamelanotide free base

330224 1.0mg
EUR 265

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TMB free base

TB0954 1g
EUR 85.06

FIPI (free base)

B2372-25 each
EUR 757.2

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EUR 235.2

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9664-25 each
EUR 1227.6

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R406 (free base)

A5880-100 100 mg
EUR 1452
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-25 25 mg
EUR 616.8
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5 5 mg
EUR 199.2
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-5.1 10 mM (in 1mL DMSO)
EUR 316.8
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406 (free base)

A5880-S Evaluation Sample
EUR 97.2
Description: R406 is a potent SYK inhibitorSpleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. It transmits signals from a variety of cell surface receptors including CD74, Fc receptor and integrins.

R406(free base)

E1KS1533 2mg
EUR 625.2

R406 (free base)

HY-11108 10mM/1mL
EUR 277.2

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FIPI free base

407955 200.0mg
EUR 1050

K201 free base

414202 5.0mg
EUR 288

S107 free base

530577 100.0mg
EUR 750

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562503 5.0mg
EUR 485

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HY-U00355 1mg
EUR 2770.8

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MS023 free base

407274 10.0mg
EUR 150

LYS01 free base

407398 10.0mg
EUR 150

ML298 free base

407464 5.0mg
EUR 240

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407496 200.0mg
EUR 2950

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407948 5.0mg
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406621 10.0mg
EUR 90

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533249 50.0mg
EUR 350

MCC950 (Free base)

B1031-1 each
EUR 183.6

MCC950 (Free base)

B1031-5 each
EUR 548.4

ITI214 (free base)

HY-12501 100mg
EUR 3531.6

RPC425 free base

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Y27632 free base

341079 1.0mg
EUR 450

LX7101 free base

522452 10.0mg
EUR 550

SHP099 free base

407376 10.0mg
EUR 150

Oxamyl Free Base

413788 100.0mg
EUR 262

Ecabet Free Base

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EUR 248

JPH203 free base

406760 5.0mg
EUR 150

LMP744 free base

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EUR 950

LGH447 free base

407201 5.0mg
EUR 450

S38093 free base

555223 100.0mg
EUR 950

ML120B free base

558369 5.0mg
EUR 90

CXD101 free base

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EUR 150

LXH254 free base

584644 5.0mg
EUR 150

SR1903 free base

574023 1.0mg
EUR 210

BGT226 free base

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EUR 250

ASN007 free base

207046 5.0mg
EUR 150

Hu7691 free base

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PLX5622 (free base)

B2965-25 25 mg
EUR 903.6

PLX5622 (free base)

B2965-5 5 mg
EUR 272.4

AZD4547, Free Base

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AZD8055, Free Base

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AZD3839 (free base)

HY-13438 50mg
EUR 1216.8

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Quinine (free base)

318603 2.0g
EUR 250

CL82198 free base

513699 10.0mg
EUR 190

SKL2001 free base

526260 50.0mg
EUR 450

SGC2085 free base

408044 50.0mg
EUR 250

Nefopam Free Base

414304 1.0g
EUR 428

Neamine Free Base

414310 1.0mg
EUR 350

Cetaben (free base)

531101 5.0mg
EUR 100

PLX5622 free base

555604 10.0mg
EUR 90

CC90001 free base

555913 25.0mg
EUR 1450

Emetine free base

564858 1.0mg
EUR 480

ASP2905 free base

565364 10.0mg
EUR 350

Exherin free base

201350 5.0mg
EUR 120

Symadex free base

201510 5.0mg
EUR 295

APTO253 free base

205517 5.0mg
EUR 280

AZD4573 free base

206979 5.0mg
EUR 450