BPA’s transgenerational disturbance to transcription of ovarian steroidogenic genes in rare minnow Gobiocypris rarus via DNA

geno-type

Evaluation of key genes and pathways in breast ductal carcinoma in situ

Breast most cancers (BC) stays the most common most cancers in females. As a result of this reality, the present analysis aimed to ascertain key genes involved inside the carcinogenesis of BC and to find their prognostic values by integrating bioinformatics devices. The gene expression profiles of 46 ductal carcinoma in situ (DCIS) and three common breast tissues from the GSE59248 dataset have been downloaded. Differentially expressed genes (DEGs) have been subsequently acknowledged using the online system GEO2R and a helpful enrichment analysis was carried out. In addition to, a protein-protein interaction (PPI) neighborhood was constructed and the best eight hub genes have been acknowledged.

 

The prognostic values of the hub genes have been extra investigated. A whole of 316 DEGs, along with 32 upregulated and 284 downregulated genes, have been acknowledged. Furthermore, eight hub genes, along with lipase E hormone delicate variety, patatin like phospholipase space containing 2, adiponectin C1Q and collagen space containing (ADIPOQ), peroxisome proliferator activated receptor γ (PPARG), fatty acid binding protein 4 (FABP4), diacylglycerol O-acyltransferase 2, lipoprotein lipase (LPL) and leptin (LEP), have been acknowledged from the PPI neighborhood.

 

The downregulated expression of ADIPOQ, PPARG, FABP4, LPL and LEP was significantly associated to poor whole survival in victims with DCIS. As a result of this reality, these genes might operate potential biomarkers for prognosis prediction. However, extra investigation is required to validate the outcomes obtained inside the present analysis.

geno-type

geno-type

 

Trametinib

T2125-1mg 1mg Ask for price
Description: Trametinib

Trametinib

T2125-50mg 50mg Ask for price
Description: Trametinib

Trametinib

T2125-5mg 5mg Ask for price
Description: Trametinib

Trametinib

abx283095-100g 100 µg Ask for price

Trametinib

abx283095-20g 20 µg
EUR 106.25

Trametinib

abx283095-50g 50 µg
EUR 237.5

Trametinib

MBS3606330-100mg 100mg
EUR 245

Trametinib

MBS3606330-10mg 10mg
EUR 200

Trametinib

MBS3606330-200mg 200mg
EUR 275

Trametinib

MBS3606330-50mg 50mg
EUR 215

Trametinib

MBS3606330-5x200mg 5x200mg
EUR 920

Trametinib-13C6

C988931 0.5mg
EUR 4669

Ripa lysate (strong)

E1WP106 50ML
EUR 60

Trametinib-d4

T712602 100mg
EUR 4500

Deiodo Trametinib

D397050 100mg
EUR 800
Description: 871700-65-1

Trametinib (GSK1120212)

A3018-200 200 mg
EUR 154
Description: MEK1 and MEK2 inhibitor, potent and selective

Trametinib (GSK1120212)

A3018-5.1 10 mM (in 1mL DMSO)
EUR 44
Description: MEK1 and MEK2 inhibitor, potent and selective

Trametinib (GSK1120212)

A3018-50 50 mg
EUR 77
Description: MEK1 and MEK2 inhibitor, potent and selective

Trametinib (GSK1120212)

A3018-500 500 mg
EUR 324
Description: MEK1 and MEK2 inhibitor, potent and selective

Trametinib (GSK1120212)

A3018-S Evaluation Sample
EUR 22
Description: MEK1 and MEK2 inhibitor, potent and selective

Trametinib (GSK1120212)

MBS576333-100mg 100mg
EUR 180

Trametinib (GSK1120212)

MBS576333-10mg 10mg
EUR 145

Trametinib (GSK1120212)

MBS576333-200mg 200mg
EUR 210

Trametinib (GSK1120212)

MBS576333-50mg 50mg
EUR 155

Trametinib (GSK1120212)

MBS576333-5mg 5mg
EUR 130

Trametinib DMSO solvate

123211 10.0mg
EUR 90

Trametinib DMSO solvate

A3887-10 10 mg
EUR 40
Description: Allosteric MEK1/MEK2 kinase inhibitor

Trametinib DMSO solvate

A3887-100 100 mg
EUR 95
Description: Allosteric MEK1/MEK2 kinase inhibitor

Trametinib DMSO solvate

A3887-5.1 10 mM (in 1mL DMSO)
EUR 44
Description: Allosteric MEK1/MEK2 kinase inhibitor

Trametinib DMSO solvate

A3887-50 50 mg
EUR 64
Description: Allosteric MEK1/MEK2 kinase inhibitor

Trametinib (DMSO solvate)

HY-10999A 100mg
EUR 256.8

Trametinib Impurity-I

T138340 10mg
EUR 800
Description: 1383430-03-2

Trametinib (DMSO Solvate)

T314310 100mg
EUR 800
Description: 1187431-43-1

Trametinib (DMSO solvate)

T5857-10mg 10mg Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)

T5857-1g 1g Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)

T5857-1mg 1mg Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)

T5857-50mg 50mg Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)

T5857-5mg 5mg Ask for price
Description: Trametinib (DMSO solvate)

Trametinib (DMSO solvate)

MBS3845880-100mg 100mg
EUR 425

Trametinib (DMSO solvate)

MBS3845880-10mg 10mg
EUR 140

Trametinib (DMSO solvate)

MBS3845880-25mg 25mg
EUR 200

Trametinib (DMSO solvate)

MBS3845880-50mg 50mg
EUR 275

Trametinib (DMSO solvate)

MBS3845880-5x100mg 5x100mg
EUR 1910

Trametinib DMSO solvate

MBS3600640-100mg 100mg
EUR 245

Trametinib DMSO solvate

MBS3600640-10mg 10mg
EUR 200

Trametinib DMSO solvate

MBS3600640-200mg 200mg
EUR 290

Trametinib DMSO solvate

MBS3600640-25mg 25mg
EUR 200

Trametinib DMSO solvate

MBS3600640-50mg 50mg
EUR 220

Trametinib DMSO solvate

MBS5752199-100mg 100mg
EUR 180

Trametinib DMSO solvate

MBS5752199-10mg 10mg
EUR 145

Trametinib DMSO solvate

MBS5752199-200mg 200mg
EUR 225

Trametinib DMSO solvate

MBS5752199-25mg 25mg
EUR 145

Trametinib DMSO solvate

MBS5752199-50mg 50mg
EUR 160

RIPA Lysis Buffer (Strong)

abx090624-100ml 100 ml
EUR 260.4

Carbol Fuchsin (ZN,Strong)

S005-125ML 1 unit
EUR 3.16
Description: Carbol Fuchsin (ZN,Strong)

Carbol Fuchsin (ZN,Strong)

S005-500ML 1 unit
EUR 10.92
Description: Carbol Fuchsin (ZN,Strong)

RIPA Lysis Buffer (Strong)

E-BC-R327-100mL 100mL
EUR 80

RIPA Lysis Buffer (Strong)

E-BC-R327-20mL 20mL
EUR 25

RIPA Lysis Buffer (Strong)

E-BC-R327-50mL 50mL
EUR 60

RIPA Lysis Buffer (Strong)

E-BC-R327-each each Ask for price

Strong RIPA Lysis Buffer

EZPS03-1 100mL
EUR 15

RIPA Lysis Buffer (Strong)

HY-K1001 100 mL
EUR 176.4

RIPA Lysis Buffer (Strong)

abx090624-100l 100 µl
EUR 150

RIPA Lysis Buffer (Strong)

abx090624-1ml 1 ml Ask for price

RIPA Lysis Buffer (Strong)

abx090624-200l 200 µl Ask for price

RIPA Lysis Buffer (Strong)

MBS355478-100mL 100mL
EUR 210

RIPA Lysis Buffer (Strong)

MBS355478-5x100mL 5x100mL
EUR 640

WB Stripping Solution Strong

05677-65 500ML
EUR 142.8

OOMC00081-10MG - Trametinib

OOMC00081-10MG 10mg
EUR 59

OOMC00081-50MG - Trametinib

OOMC00081-50MG 50mg
EUR 199

Trametinib [CAS# 871700-17-3]

T-8123 10 mg
EUR 38

Trametinib dimethyl sulfoxide

414033 25.0mg
EUR 228

Clear Seal Strong Sheet (100)

MAAB-0685 each
EUR 255.61

HiDecal (Strong decalcifying solution)

R085-500ML 1 unit
EUR 21.95
Description: HiDecal (Strong decalcifying solution)

Arg-SEC Mobile Phase(Strong)

17000-51 1L
EUR 105

Pierce Seal Strong Roll - 1ROLL

PCR0636 1ROLL
EUR 1314.9

GSK1120212 (JTP-74057, Trametinib)

MBS384815-100mg 100mg
EUR 210

GSK1120212 (JTP-74057, Trametinib)

MBS384815-10mg 10mg
EUR 145

GSK1120212 (JTP-74057, Trametinib)

MBS384815-1mLinDMSO 1mL(inDMSO)
EUR 145

GSK1120212 (JTP-74057, Trametinib)

MBS384815-50mg 50mg
EUR 170

GSK1120212 (JTP-74057, Trametinib)

MBS384815-5mg 5mg
EUR 130

Pierce Seal Strong Sheets - PK100

PCR0632 PK100
EUR 140.4

Tissue/cell lysis buffer(Strong)

RM17482 10mL
EUR 53.14

Modified Duncan Strong (DS) Medium

M1237-500G 1 unit
EUR 80.55
Description: Modified Duncan Strong (DS) Medium

replacement tip Kit strong thick

INS2090 EACH
EUR 8.33

Pierce Seal Strong Roll610mX78mm - 1ROLL

PCR0628 1ROLL
EUR 1104.3

Western Stripping buffer (Strong alkaline)

EZWB03-1-100mL 100mL
EUR 9.6

Western Stripping buffer (Strong alkaline)

EZWB03-1-500mL 500mL
EUR 28.8

Trametinib, DMSO Solvate [CAS# 1187431-43-1]

T-8188 10 mg
EUR 38

PCR Foil Seal Strong Sheets - PK100

PCR0528 PK100
EUR 211.95

Tweezers Fine Strong CF Tips - EACH

INS5058 EACH
EUR 37.6

Tweezers Flat Strong CF Tips - EACH

INS5100 EACH
EUR 43.92

EP Reagent Sodium Hypochlorite Sol. Strong - 500ML

10816005 500ML
EUR 136.35

Pierce Seal Strong Sample Roll - 1ROLL

PCR0630 1ROLL
EUR 59.63

replacement tip Kit strong thick - EACH

INS2058 EACH
EUR 11.65

replacement tip Kit strong point - EACH

INS2094 EACH
EUR 11.65

Modified Duncan Strong (DS) HiVeg Medium

MV1237-500G 1 unit
EUR 80.55
Description: Modified Duncan Strong (DS) HiVeg Medium

anti PAI-1 (very strong for human)

MBS480230-1mg 1mg
EUR 790

anti PAI-1 (very strong for human)

MBS480230-5x1mg 5x1mg
EUR 3315

Strong RIPA Lysis Buffer (without inhibitors)

EZPS03-2 100mL
EUR 12.6

EP Reagent Sodium Hydroxide Sol. Strong - 1L

1081404 1L
EUR 191.7

Tweezers, Rubis Sturdy, Strong Pointed, 115mm, 4.5€

25046-1 1EA
EUR 48

Silver Protein for Histology, Strong (not certified)

25108-25 25g
EUR 431
Description: 9015-51-4

Silver Protein for Histology, Strong (not certified)

25108-5 5g
EUR 113
Description: 9015-51-4

Magnetic Base Support Z w/ Strong Magnet - 34.5mm

M-R-1013161 1 UNIT
EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 34.5mm

Magnetic Base Support Z w/ Strong Magnet - 27.5mm

M-R-1015229 1 UNIT
EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 27.5mm

Seralite SRC-120, Strong Acid Cation Exchange Resin

14891 500 Gms
EUR 3.76
Description: Part A

Seralite SRA-400, Strong Basic Anion Exchange Resin

52228 500 Gms
EUR 5.82
Description: Part A

UCW5072, Low TOC Strong Base Anion Resin, OH Form

50240-1 1000ml
EUR 192

UCW5072, Low TOC Strong Base Anion Resin, OH Form

50240-250 250ml
EUR 62

DiagAg™ Strong Anion Exchange Agarose Particles, 40 μm

DAG-CL23-08 25 mL
EUR 1150

A510, Type 2 Macroporous Strong Base Resin, Chloride Form

50223-250 250ml
EUR 47
Description: 69011-15-0

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form

50218-1 1000ml
EUR 144
Description: 9052-45-3

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form

50218-250 250ml
EUR 47
Description: 9052-45-3

Optically clear sealing film for qPCR, Strong Bond, for PP plates, 100/pk

MS1000-PCR2 1 each
EUR 149.35

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 24-45 µm

DAG-YS23-27 25 mL
EUR 850

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, Low Capacity

DAG-YS23-28 25 mL
EUR 850

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, High Capacity

DAG-YS23-29 25 mL
EUR 850

Foil seals, strong bonding for cold storage (-200 to 110°C) and DMSO, for PP plates, 100/pk

MS1000-F2 1 each
EUR 149.35

Estrogen receptor (ER) IHC control with strong, moderate, low/negative expressersHumanBreastBreastIHC control

ERC083 1.5mm
EUR 50

 

A prognosis-predictive nomogram of ovarian most cancers with two immune-related genes: CDC20B and PNPLA5

 

Ovarian carcinoma (OV) is probably going one of the lethal gynecological malignancies globally, and the overall 5-year survival cost of OV was 47% in 2018 primarily based on American info. To increase the survival cost of victims with OV, many researchers have sought to ascertain biomarkers that act as every prognosis-predictive markers and treatment targets.

 

However, most of these have not been acceptable for scientific software program. The present analysis geared towards establishing a predictive prognostic nomogram of OV using the genes acknowledged by combining The Most cancers Genome Atlas (TCGA) dataset for OV with the immune ranking calculated by the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression info algorithm. Firstly, the algorithm was used to calculate the immune ranking of victims with OV inside the TCGA-OV dataset.

 

Secondly, differentially expressed genes (DEGs) between excessive and low immune ranking tissues have been acknowledged, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis was carried out to predict the options of these DEGs. Thirdly, univariate, multivariate and Lasso Cox’s regression analyses have been carried out step-by-step, and 6 prognosis-relatedDEGs have been acknowledged.

 

Then, Kaplan-Myer survival curves have been generated for these genes and validated by evaluating their expression ranges to extra slender the fluctuate of DEGs and to calculate the hazard ranking. Two genes have been acknowledged, cell division cycle 20B and patatin-like phospholipase space containing 5, which have been every confirmed to have elevated expression ranges in OV tissues and to be significantly associated to the prognosis of OV.

 

Subsequent, a nomogram was created using these two genes and age, and using the receiver working attribute (ROC) curve and calibration curve, the effectiveness of the nomogram was validated. Lastly, an exterior validation was carried out for this nomogram. The ROC confirmed that the areas beneath the curve (AUCs) of the 3- and 5-year whole survival predictions for the nomogram have been 0.678 and 0.62, respectively. Moreover, the ROC of the outside validation model confirmed that the AUCs of the 3- and 5-year have been 0.699 and 0.643, respectively, demonstrating the effectiveness of the generated nomogram. In conclusion, the present analysis has acknowledged two immune-related genes as biomarkers that reliably predict whole survival in OV. These biomarkers may additionally be potential molecular targets of immune treatment to take care of victims with OV.

Evolution of the Brassicaceae-specific MS5-Like household and neofunctionalization of the novel MALE STERILITY 5 gene important for male fertility in B. napus

 

New genes (or lineage-specific genes) can facilitate useful improvements. MALE STERILITY 5 (MS5) in Brassica napus is a fertility-related new gene, which has two wild kind alleles (BnMS5a and BnMS5c ) and two mutant alleles (BnMS5b and BnMS5d ) that might induce male sterility.
Right here, we studied the historical past and useful evolution of MS5 homologs in crops by phylogenetic evaluation and molecular genetic experiments. We recognized 727 MS5 homologs and located that they outline a Brassicaceae-specific gene household that has expanded partly through a number of tandem gene duplications and likewise in all probability transpositions. The MS5 in B. napus is inherited from a fundamental diploid ancestor of B. rapa.
Molecular genetic experiments point out that BnMS5a and BnMS5c are functionally distinct in B. napus and that BnMS5d can inhibit BnMS5a in B. napus in a dosage-dependent method.
The BnMS5a protein can transfer in coordination with meiotic telomeres and work together with the nuclear envelope protein SUN1, with a potential essential position in meiotic chromosome habits. In abstract, BnMS5 belongs to a Brassicaceae-specific new gene household, and has gained a novel operate that’s important for male fertility in B. napus via neofunctionalization that has doubtless occurred because the origin of B. rapa.

BPA’s transgenerational disturbance to transcription of ovarian steroidogenic genes in uncommon minnow Gobiocypris rarus through DNA and histone methylation

As a well known estrogenic endocrine disruptor, bisphenol A (BPA) is of utmost concern since it’s reported with dangerous results on animal copy. Nonetheless, the opposed results on progeny after parental BPA publicity are largely unknown in fishes.
To analyze the epigenetic results of BPA on progeny gonadal growth, parental uncommon minnow (Gobiocypris rarus) had been uncovered to BPA (15 μg L-1) for 2 months, then had been purged in clear water for one, two or three months, respectively. From the second month, dad and mom had been mated as soon as a month and the offspring had been reared to five months previous.
Outcomes confirmed that parental BPA publicity inhibited the ovary growth of the offspring by decreasing the variety of mature oocytes whereas the transcripts of steroidogenic genes (cyp11a1, cyp17a1, cyp19a1a and star) had been considerably affected. And the detrimental results of parental BPA publicity on the offspring had been reversible.
The DNA methylation and histone trimethylation ranges (H3K9me3 and H3K27me3) along with the expression of dnmts (dnmt1, dnmt5 and dnmt7) and histone methyltransferase genes (setdb1, setdb2 and ezh2) had been considerably altered within the ovaries of the 5-month previous offsprings.
BPA interfered the expression of steroidogenic genes by altering histone recruitment in star (H3K4me3 and H3K9me3), in cyp11a1 and cyp17a1 (H3K9me3 and H3K27me3), in addition to in cyp19a1a (H3K4me3, H3K9me3 and H3K27me3).
As well as, altering of DNA methylation at CpG website brought on by BPA publicity concerned within the regulation of star, cyp17a1 and cyp19a1a expression. These outcomes recommend that BPA transgenerationally imposes detriment to copy and the epigenetic adjustments in DNA methylation and histone trimethylation may account for steroidogenic genes expression.

RIPA Lysis Buffer (Strong)

abx090624-100l 100 µl
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RIPA Lysis Buffer (Strong)

abx090624-1ml 1 ml Ask for price

RIPA Lysis Buffer (Strong)

abx090624-200l 200 µl Ask for price

RIPA Lysis Buffer (Strong)

MBS355478-100mL 100mL
EUR 210

RIPA Lysis Buffer (Strong)

MBS355478-5x100mL 5x100mL
EUR 640

WB Stripping Solution Strong

05677-65 500ML
EUR 142.8

Clear Seal Strong Sheet (100)

MAAB-0685 each
EUR 255.61

HiDecal (Strong decalcifying solution)

R085-500ML 1 unit
EUR 21.95
Description: HiDecal (Strong decalcifying solution)

Arg-SEC Mobile Phase(Strong)

17000-51 1L
EUR 105

Pierce Seal Strong Roll - 1ROLL

PCR0636 1ROLL
EUR 1314.9

Pierce Seal Strong Sheets - PK100

PCR0632 PK100
EUR 140.4

Tissue/cell lysis buffer(Strong)

RM17482 10mL
EUR 53.14

Modified Duncan Strong (DS) Medium

M1237-500G 1 unit
EUR 80.55
Description: Modified Duncan Strong (DS) Medium

replacement tip Kit strong thick

INS2090 EACH
EUR 8.33

Pierce Seal Strong Roll610mX78mm - 1ROLL

PCR0628 1ROLL
EUR 1104.3

Western Stripping buffer (Strong alkaline)

EZWB03-1-100mL 100mL
EUR 9.6

Western Stripping buffer (Strong alkaline)

EZWB03-1-500mL 500mL
EUR 28.8

PCR Foil Seal Strong Sheets - PK100

PCR0528 PK100
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Tweezers Fine Strong CF Tips - EACH

INS5058 EACH
EUR 37.6

Tweezers Flat Strong CF Tips - EACH

INS5100 EACH
EUR 43.92

EP Reagent Sodium Hypochlorite Sol. Strong - 500ML

10816005 500ML
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Pierce Seal Strong Sample Roll - 1ROLL

PCR0630 1ROLL
EUR 59.63

replacement tip Kit strong thick - EACH

INS2058 EACH
EUR 11.65

replacement tip Kit strong point - EACH

INS2094 EACH
EUR 11.65

Modified Duncan Strong (DS) HiVeg Medium

MV1237-500G 1 unit
EUR 80.55
Description: Modified Duncan Strong (DS) HiVeg Medium

anti PAI-1 (very strong for human)

MBS480230-1mg 1mg
EUR 790

anti PAI-1 (very strong for human)

MBS480230-5x1mg 5x1mg
EUR 3315

Strong RIPA Lysis Buffer (without inhibitors)

EZPS03-2 100mL
EUR 12.6

EP Reagent Sodium Hydroxide Sol. Strong - 1L

1081404 1L
EUR 191.7

Tweezers, Rubis Sturdy, Strong Pointed, 115mm, 4.5€

25046-1 1EA
EUR 48

Silver Protein for Histology, Strong (not certified)

25108-25 25g
EUR 431
Description: 9015-51-4

Silver Protein for Histology, Strong (not certified)

25108-5 5g
EUR 113
Description: 9015-51-4

Magnetic Base Support Z w/ Strong Magnet - 34.5mm

M-R-1013161 1 UNIT
EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 34.5mm

Magnetic Base Support Z w/ Strong Magnet - 27.5mm

M-R-1015229 1 UNIT
EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 27.5mm

Seralite SRC-120, Strong Acid Cation Exchange Resin

14891 500 Gms
EUR 3.76
Description: Part A

Seralite SRA-400, Strong Basic Anion Exchange Resin

52228 500 Gms
EUR 5.82
Description: Part A

UCW5072, Low TOC Strong Base Anion Resin, OH Form

50240-1 1000ml
EUR 192

UCW5072, Low TOC Strong Base Anion Resin, OH Form

50240-250 250ml
EUR 62

DiagAg™ Strong Anion Exchange Agarose Particles, 40 μm

DAG-CL23-08 25 mL
EUR 1150

A510, Type 2 Macroporous Strong Base Resin, Chloride Form

50223-250 250ml
EUR 47
Description: 69011-15-0

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form

50218-1 1000ml
EUR 144
Description: 9052-45-3

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form

50218-250 250ml
EUR 47
Description: 9052-45-3

Optically clear sealing film for qPCR, Strong Bond, for PP plates, 100/pk

MS1000-PCR2 1 each
EUR 149.35

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 24-45 µm

DAG-YS23-27 25 mL
EUR 850

Rapamycin

20-abx076788
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Rapamycin

1568-5 each
EUR 339.6

Rapamycin

1568-50 each
EUR 1396.8

Rapamycin

30037-94 100UG
EUR 138.6

Rapamycin

27062 50 mg
EUR 135
Description: Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM).

Rapamycin

41810000-1 10 mg
EUR 52.16

Rapamycin

41810000-2 100 mg
EUR 161.05

Rapamycin

41810000-3 50 mg
EUR 89.68

Rapamycin

41810000-4 500 mg
EUR 364.2

Rapamycin

20-abx185560
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Rapamycin

E1B1842 1mg
EUR 60

Rapamycin

tlrl-rap-5 5 x 5 mg
EUR 248.85

Rapamycin

GA7417 5mg
EUR 181.03

Rapamycin

G613 100 mg
EUR 800

Rapamycin

MBS132175-100mg 100mg
EUR 1065

Rapamycin

MBS132175-500mg 500mg
EUR 2775

Rapamycin

HY-10219 200mg
EUR 241.2

Rapamycin

GA7417-100 100
EUR 197.7

Rapamycin

GA7417-100MG 100 mg
EUR 274.8

Rapamycin

GA7417-25 25
EUR 63.3

Rapamycin

GA7417-25MG 25 mg
EUR 112.8

Rapamycin

GA7417-5 5
EUR 23.8

Rapamycin

GA7417-50 50
EUR 118.7

Rapamycin

GA7417-50MG 50 mg
EUR 180

Rapamycin

GA7417-5MG 5 mg
EUR 64.8

Rapamycin

R001-10MG 10 mg
EUR 149.37
Description: C51H79NO13

Rapamycin

R001-25MG 25 mg
EUR 187.13
Description: C51H79NO13

Rapamycin

SIH-212-25MG 25 mg
EUR 345
Description: mTOR inhibitor

Rapamycin

SIH-212-5MG 5 mg
EUR 138
Description: mTOR inhibitor

Rapamycin

T1537-10mg 10mg Ask for price
Description: Rapamycin

Rapamycin

T1537-1g 1g Ask for price
Description: Rapamycin

Rapamycin

T1537-1mg 1mg Ask for price
Description: Rapamycin

Rapamycin

T1537-50mg 50mg Ask for price
Description: Rapamycin

Rapamycin

T1537-5mg 5mg Ask for price
Description: Rapamycin

Rapamycin

abx076788-100l 100 µl
EUR 118.75

Rapamycin

abx076788-1ml 1 ml Ask for price

Rapamycin

abx076788-200l 200 µl
EUR 300

Rapamycin

MBS696245-10mg 10mg
EUR 235

Rapamycin

MBS696245-1mg 1mg
EUR 135

Rapamycin

MBS696245-5x10mg 5x10mg
EUR 1005

Rapamycin

MBS807957-25mg 25mg
EUR 450

Rapamycin

MBS807957-5mg 5mg
EUR 260

Rapamycin

MBS807957-5x25mg 5x25mg
EUR 1770

Rapamycin

MBS807957-5x5mg 5x5mg
EUR 905

Rapamycin

MBS8579821-1mg 1mg
EUR 155

Rapamycin

MBS8579821-5x1mg 5x1mg
EUR 555

Rapamycin

MBS407517-100mg 100mg
EUR 175

Rapamycin

MBS407517-1g 1g
EUR 450

Rapamycin

MBS407517-5x100mg 5x100mg
EUR 730

Rapamycin

MBS407517-5x1g 5x1g
EUR 1970

Rapamycin

MBS3604884-100mg 100mg
EUR 210

Rapamycin

MBS3604884-200mg 200mg
EUR 240

Rapamycin

MBS3604884-50mg 50mg
EUR 195

Rapamycin

MBS3604884-5x200mg 5x200mg
EUR 760

Rapamycin

MBS515013-100mg 100mg
EUR 665

Rapamycin

MBS515013-20mg 20mg
EUR 320

Rapamycin

MBS515013-5x100mg 5x100mg
EUR 2740

Rapamycin, 100mg

R5312 100mg
EUR 607.18

Rapamycin, 100mg

R5312-100mg each
EUR 902.4

Rapamycin, >99%

BC082-050 50mg
EUR 262.8

Rapamycin, >99%

BC082-100 100mg
EUR 313.2

Rapamycin, >99%

BC082-250 250mg
EUR 424.8

Rapamycin, >99%

BC082-500 500mg
EUR 651.6

Rapamycin (>85%)

R124000 100mg
EUR 80
Description: 53123-88-9

Seco Rapamycin

HY-19555 50mg
EUR 2704.8

Rapamycin, 10mg

R5312-10mg each
EUR 244.8

Rapamycin-d3

T12691-10mg 10mg Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-1g 1g Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-1mg 1mg Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-50mg 50mg Ask for price
Description: Rapamycin-d3

Rapamycin-d3

T12691-5mg 5mg Ask for price
Description: Rapamycin-d3

Seco Rapamycin

T38963-10mg 10mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-1g 1g Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-1mg 1mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-50mg 50mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

T38963-5mg 5mg Ask for price
Description: Seco Rapamycin

Seco Rapamycin

MBS5799522-5mg 5(mg
EUR 915

Seco Rapamycin

MBS5799522-5x5mg 5x5(mg
EUR 3970

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, Low Capacity

DAG-YS23-28 25 mL
EUR 850

DiagAg™ Phenyl Agarose Strong Hydrophobic Medium, 6% Crosslinked, 45-165 µm, High Capacity

DAG-YS23-29 25 mL
EUR 850

Sirolimus (Rapamycin)

100766 25.0mg
EUR 90

Rapamycin (Sirolimus)

E1KS1039 50mg
EUR 120

Rapamycin (Sirolimus)

A8167-100 100 mg
EUR 154
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-25 25 mg
EUR 74
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-5 5 mg
EUR 33
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-5.1 10 mM (in 1mL DMSO)
EUR 48
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

A8167-S Evaluation Sample
EUR 22
Description: Original antifungal antibiotic

Rapamycin (Sirolimus)

MBS8506576-50mg 50mg
EUR 210

Rapamycin (Sirolimus)

MBS8506576-5x50mg 5x50mg
EUR 800

Rapamycin (Sirolimus)

MBS386035-100mg 100mg
EUR 160

Rapamycin (Sirolimus)

MBS386035-1mLinDMSO 1mL(inDMSO)
EUR 140

Rapamycin (Sirolimus)

MBS386035-50mg 50mg
EUR 145

Rapamycin (Sirolimus)

MBS386035-5mg 5mg
EUR 130

Rapamycin (Sirolimus)

MBS386035-5x100mg 5x100mg
EUR 715

Rapamycin (Sirolimus)

MBS575148-100mg 100mg
EUR 155

Rapamycin (Sirolimus)

MBS575148-200mg 200mg
EUR 185

Rapamycin (Sirolimus)

MBS575148-25mg 25mg
EUR 135

Rapamycin (Sirolimus)

MBS575148-500mg 500mg
EUR 260

Rapamycin (Sirolimus)

MBS575148-50mg 50mg
EUR 145

Foil seals, strong bonding for cold storage (-200 to 110°C) and DMSO, for PP plates, 100/pk

MS1000-F2 1 each
EUR 149.35

EZSolution? Rapamycin

1746-5 each
EUR 326.4

Estrogen receptor (ER) IHC control with strong, moderate, low/negative expressersHumanBreastBreastIHC control

ERC083 1.5mm
EUR 50

rapamycin derivative 1

R454500 25mg
EUR 1800

rapamycin derivative 2

R574880 100mg
EUR 9200

TOR | Target of rapamycin

AS12-2608 50 µg
EUR 302

OOMC00007-10MG - Rapamycin

OOMC00007-10MG 10mg
EUR 69

OOMC00007-50MG - Rapamycin

OOMC00007-50MG 50mg
EUR 249

Rapamycin-31,42-Diester Impurity

R124015 50mg
EUR 1938

Rapamycin [CAS# 53123-88-9]

R-5000 50 mg
EUR 48

33-O-Formyl Rapamycin

F699010 10mg
EUR 1728

Seco Rapamycin (sodium salt)

HY-19555A 1mg
EUR 207.6

7-O-Demethyl rapamycin

T25882-10mg 10mg Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-1g 1g Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-1mg 1mg Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-50mg 50mg Ask for price
Description: 7-O-Demethyl rapamycin

7-O-Demethyl rapamycin

T25882-5mg 5mg Ask for price
Description: 7-O-Demethyl rapamycin

Seco Rapamycin sodium salt

T19558-10mg 10mg Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-1g 1g Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-1mg 1mg Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-50mg 50mg Ask for price
Description: Seco Rapamycin sodium salt

Seco Rapamycin sodium salt

T19558-5mg 5mg Ask for price
Description: Seco Rapamycin sodium salt

7-O-Demethyl Rapamycin

MBS6080732-25mg 2.5(mg
EUR 665

7-O-Demethyl Rapamycin

MBS6080732-5x25mg 5x2.5mg
EUR 2845

7-O-Demethyl rapamycin

MBS5775613-10mg 10mg
EUR 2020

7-O-Demethyl rapamycin

MBS5775613-25mg 25mg
EUR 1995

7-O-Demethyl rapamycin

MBS5775613-5mg 5(mg
EUR 1235

Seco Rapamycin sodium salt

MBS3602049-10mg 10mg
EUR 655

Seco Rapamycin sodium salt

MBS3602049-25mg 25mg
EUR 1075

Seco Rapamycin sodium salt

MBS3602049-50mg 50mg
EUR 1630

Seco Rapamycin sodium salt

MBS3602049-5mg 5mg
EUR 465

Seco Rapamycin sodium salt

MBS3602049-5x50mg 5x50mg
EUR 7015

Seco Rapamycin sodium salt

MBS5756112-25mg 25mg
EUR 1405

Seco Rapamycin sodium salt

MBS5756112-50mg 50mg
EUR 2410

Seco Rapamycin sodium salt

MBS5756112-5x50mg 5x50mg
EUR 10695

42-(2-Tetrazolyl)rapamycin

HY-12424A 1mg
EUR 241.2

42-(2-Tetrazolyl)rapamycin

T10158-10mg 10mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-1g 1g Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-1mg 1mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-50mg 50mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

T10158-5mg 5mg Ask for price
Description: 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin

MBS3845824-100mg 100mg
EUR 3100

42-(2-Tetrazolyl)rapamycin

MBS3845824-10mg 10mg
EUR 575

42-(2-Tetrazolyl)rapamycin

MBS3845824-50mg 50mg
EUR 1585

42-(2-Tetrazolyl)rapamycin

MBS3845824-5mg 5mg
EUR 355

42-(2-Tetrazolyl)rapamycin

MBS3845824-5x100mg 5x100mg
EUR 13945

42-(2-Tetrazolyl)rapamycin

MBS5752629-50mg 50mg
EUR 1325